Patterns of Positive Selection in Six Mammalian Genomes
نویسندگان
چکیده
منابع مشابه
Patterns of Positive Selection in Six Mammalian Genomes
Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight into the dynamics of genome evolution, the genetic basis of differences between species, and the functions of individual genes. However, previous scans have been limited in power and accuracy owing to small numbers of available genomes. Here we present the most comprehensive examination of mammalian PSGs to ...
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To accurately identify orthologous sequences in the six mammalian species, we used syntenic whole-genome alignments produced by the MULTIZ program [1] on the following assemblies available through the UCSC genome browser [2]: human (hg18), chimpanzee (panTro2), macaque (rheMac2), mouse (mm8), rat (rn4), and dog (canFam2). The human genome was used as a reference genome. We used the pairwise syn...
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The question of how duplicate genes are retained in a population remains controversial. The duplication-degeneration-complementation model, which involves no positive selection, stipulates a higher retention rate of duplicate genes in a small population than in a large one. This model has been accepted by many evolutionists. However, we found considerably more retentions and fewer losses of dup...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2008
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000144